Self-guided interventions, although associated with only small to medium effects on individuals, can reach a larger number of patients and may thus have a larger public health impact. Nevertheless, although the scalability of web-based interventions with guidance is higher than that of traditional psychotherapy, it is limited because staff resources are required, even if the time allotted for guidance is limited. Besides within-intervention guidance, guidance-related aspects of the study design such as the conduct of clinical interviews, use of automated reminders, or treatment setting in which the intervention is used seem to be associated with greater effects. Guided digital interventions often yield larger effects than self-guided interventions (eg, the studies by Koelen et al, Lakhtakia and Torous, Moshe et al, and Schröder et al ), but a recent meta-analysis revealed that overall, the difference in effect sizes may not be very substantial, at least concerning anxiety disorders. Interventions targeting the same disorder tend to be similar in terms of their components and content. These interventions consist of several subsequent sessions or modules. Most digital interventions address singular disorder categories and are structured similarly to disorder-specific treatment manuals. The efficacy of digital interventions has been shown for both the reduction of symptoms of common mental disorders and improvement of quality of life. Digital Mental Health Interventions May Reduce Symptom Burden
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